Dissolution Behaviours of Acetaminophen and Ibuprofen Tablet Influenced By L–HPC 21, 22, and Sodium Starch Glycolate as Disintegrant
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چکیده
منابع مشابه
Evaluation of Abelmoschus starch as tablet disintegrant
Seed starch (16.0%w/w) obtained from Abelmoschus moschatus Linn. (Malvaceae) was employed as a disintegrant to paracetamol tablets at concentrations of 2.5-10.0% w/w. The granules prepared by wet granulation technique were evaluated for percentage of fines and flow properties. Tablet properties including thickness, content uniformity, average weight and weight variation, hardness, friability, d...
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VENKATESKUMAR KRISHNAMOORTHY1,2*, VERMA PRIYA RANJAN PRASAD3 AND SUCHANDRASEN SEN1 1Department of Pharmaceutics, Kovai Medical Center and Hospital (KMCH) College of Pharmacy, Coimbatore 641048, India 2Faculty of Pharmacy, Asian Institute of Medical Science and Technology (AIMST) University, 08100 Semeling, Kedah, Malaysia 3Department of Pharmaceutical Sciences, Birla Institute of Technology, Me...
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The effect, of varying the proportion of binder starch paste (SP) and the disintegrant sodium starch glycolate (SSG), on the compaction behavior of wet granulated acetaminophen (ACM) formulations using a fully instrumented rotary tablet press, was studied. Wet granulation formulations were prepared using ACM, SP as binder (equal to 2.5%, 5% or 10% starch concentration), SSG as disintegrant (0%,...
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In the past few years, there are number of researchers carrying out their research on the excipients derived from polysaccharides and some of these researches show that natural excipients are comparable and can serve as an alternative to the synthetic excipients. Hence, the objectives of this research are to characterize the naturally sourced chickpea starch powder and to study the pharmaceutic...
متن کاملStudies on disintegrant action of Leucaena leucocephala seed gum in ibuprofen tablet and its mechanism
Leucaena (Leucaena leucocephala) seed gum (LSG) was evaluated for disintegrant action in lactose (soluble) based tablets containing ibuprofen, a relatively insoluble drug. The properties of tablets evaluated include weight uniformity, hardness, friability, disintegration time and in vitro dissolution (k, T 50 , A 30 ). LSG, at low concentration level (2% w/w), can be used as a disintegrant in t...
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ژورنال
عنوان ژورنال: Indonesian Journal of Pharmaceutics
سال: 2019
ISSN: 2597-8748
DOI: 10.24198/idjp.v1i3.23508